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Antimicrobial Agents and Chemotherapy, February 2009, p. 839-842, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.00062-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Antileishmanial Activity of 1,3,4-Thiadiazolium-2-Aminide in Mice Infected with Leishmania amazonensis{triangledown}

Raquel F. Rodrigues,1 Karen S. Charret,1 Edson F. da Silva,2 Áurea Echevarria,2 Verônica F. Amaral,3 Leonor L. Leon,1 and Marilene M. Canto-Cavalheiro1*

Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz/Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil CEP 21045-900,1 Departamento de Química, Instituto de Ciências Exatas, Universidade Federal Rural do Rio de Janeiro, RJ, Brazil,2 Departamento de Imunobiologia, Instituto de Biologia, Universidade Federal Fluminense—Niterói, RJ, Brazil3

Received 15 January 2008/ Returned for modification 22 March 2008/ Accepted 9 November 2008

The efficacy of two mesoionic derivatives (MI-H-H and MI-4-OCH3) was evaluated in CBA/J mice infected with Leishmania amazonensis. Treatment with these compounds demonstrated that the MI-4-OCH3 derivative and the reference drug meglumine antimoniate (Glucantime) presented significant activity relative to an untreated control. No apparent hepatic or renal toxicity due to these mesoionic compounds was found.

* Corresponding author. Mailing address: Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz/Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil CEP 21045-900. Phone: 55 21 38658225. Fax: 55 21 22900479. E-mail: mcantocavalheiro{at}hotmail.com

{triangledown} Published ahead of print on 17 November 2008.

Antimicrobial Agents and Chemotherapy, February 2009, p. 839-842, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.00062-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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