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Antimicrobial Agents and Chemotherapy, March 2009, p. 1213-1217, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.00126-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Theileria Apicoplast as a Target for Chemotherapy{triangledown} ,{dagger}

Regina Lizundia,1 Dirk Werling,2 Gordon Langsley,1 and Stuart A. Ralph3*

Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, UMR 8104 CNRS/U567 INSERM, Département Maladies Infectieuses, Hôpital Cochin—Bâtiment Gustave Roussy, Institut Cochin, 27 rue du Faubourg-Saint-Jacques, 75014 Paris, France,1 Royal Veterinary College, Department of Pathology and Infectious Diseases, Hawkshead Lane, Hatfield, Hertfordshire AL9 7TA, United Kingdom,2 Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia3

Received 28 January 2008/ Returned for modification 1 April 2008/ Accepted 3 December 2008

Theileria parasites cause severe bovine disease and death in a large part of the world. These apicomplexan parasites possess a relic plastid (apicoplast), whose metabolic pathways include several promising drug targets. Putative inhibitors of these targets were screened, and we identified antiproliferative compounds that merit further characterization.

* Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia. Phone: 61 3 8344 2284. Fax: 61 3 9348 1421. E-mail: saralph{at}unimelb.edu.au

{triangledown} Published ahead of print on 15 December 2008.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, March 2009, p. 1213-1217, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.00126-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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