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Antimicrobial Agents and Chemotherapy, March 2009, p. 1225-1227, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.01011-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Carbapenem Resistance among Pseudomonas aeruginosa Strains from India: Evidence for Nationwide Endemicity of Multiple Metallo-β-Lactamase Clones (VIM-2, -5, -6, and -11 and the Newly Characterized VIM-18){triangledown}

Mariana Castanheira,1* Jan M. Bell,2 John D. Turnidge,2 Dillip Mathai,3 and Ronald N. Jones1,4

JMI Laboratories, North Liberty, Iowa 52317,1 Women's and Children's Hospital, Adelaide, Australia,2 Christian Medical College, Vellore, India,3 Tufts University School of Medicine, Boston, Massachusetts 021104

Received 28 July 2008/ Returned for modification 31 August 2008/ Accepted 21 December 2008

Among 57 metallo-β-lactamase (MβL)-producing Pseudomonas spp. detected in India during 2006, five blaVIM genes were found, including a newly characterized blaVIM gene. Pseudomonas aeruginosa strains were clustered in 33 ribotypes with clones found in multiple hospitals. Several types of blaVIM-2-carrying integrons were detected. The newly characterized variant VIM-18 showed a 4-amino-acid deletion compared to other VIM variants. In this study, we show that VIM-producing Pseudomonas spp. were highly prevalent in India with a great diversity of blaVIM types and MβL-carrying integrons.

* Corresponding author. Mailing address: 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317. Phone: (319) 665-3370. Fax: (319) 665-3371. E-mail: mariana-castanheira{at}jmilabs.com

{triangledown} Published ahead of print on 29 December 2008.

Antimicrobial Agents and Chemotherapy, March 2009, p. 1225-1227, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.01011-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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