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Antimicrobial Agents and Chemotherapy, March 2009, p. 1235-1237, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.00970-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Mobilization of qnrB2 and ISCR1 in Plasmids{triangledown}

Ying-Tsong Chen,1,{dagger}* Tsai-Lien Liao,1,{dagger} Yen-Ming Liu,1 Tsai-Ling Lauderdale,2 Jing-Jou Yan,3 and Shih-Feng Tsai1,4,5

Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan,1 Division of Clinical Research, National Health Research Institutes, Miaoli, Taiwan,2 Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan,3 Genome Research Center and Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan,4 and Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan5

Received 22 July 2008/ Returned for modification 1 November 2008/ Accepted 6 December 2008

The DNA sequences of two IncHI2 plasmids, pEC-IMP and pEC-IMPQ, from metallo-β-lactamase-producing Enterobacter cloacae clinical isolates were determined. The two conjugative plasmids are almost identical, but pEC-IMPQ carries an additional segment containing an orf513 (ISCR1), a truncated 3' conserved sequence, and a qnrB2. Comparative analyses provide support for the proposed ISCR1-mediated gene mobilization.

* Corresponding author. Mailing address: 35 Keyan Rd., Zhunan Town, Miaoli County 350, Taiwan. Phone: 886-37246166, ext. 35345. Fax: 886-37586459. E-mail: onion{at}nhri.org.tw

{triangledown} Published ahead of print on 15 December 2008.

{dagger} These authors contributed equally to this article.

Antimicrobial Agents and Chemotherapy, March 2009, p. 1235-1237, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.00970-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



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