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Antimicrobial Agents and Chemotherapy, March 2009, p. 1245-1247, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.00801-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Antimicrobial Activities of Jadomycin B and Structurally Related Analogues{triangledown}

David L. Jakeman,1,2* Srinivasulu Bandi,1,3 Cathy L. Graham,1 Taryn R. Reid,1 Jason R. Wentzell,1 and Susan E. Douglas3

College of Pharmacy, Dalhousie University, 5968 College St., Halifax, Nova Scotia B3H 3J5, Canada,1 Department of Chemistry, Dalhousie University, Halifax, Nova Scotia B3H 4J3, Canada,2 Institute for Marine Biosciences, National Research Council of Canada, Halifax, Nova Scotia B3H 3Z1, Canada3

Received 18 June 2008/ Returned for modification 8 October 2008/ Accepted 8 December 2008

Natural products are leads for new antibiotics as a result of their structural complexity and diversity. We have isolated a series of structurally related polyketide-derived natural products from Streptomyces venezuelae ISP5230. The most active of these jadomycin analogues showed good activity against a variety of staphylococci, including methicillin-resistant Staphylococcus aureus.

* Corresponding author. Mailing address: College of Pharmacy, 5968 College St., Halifax, Nova Scotia B3H3J5, Canada. Phone: (902) 494-7159. Fax: (902) 494-1396. E-mail: david.jakeman{at}dal.ca

{triangledown} Published ahead of print on 15 December 2008.

Antimicrobial Agents and Chemotherapy, March 2009, p. 1245-1247, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.00801-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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