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Antimicrobial Agents and Chemotherapy, March 2009, p. 1248-1251, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.00480-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Molecular Analysis of the Sequences Surrounding blaOXA-45 Reveals Acquisition of This Gene by Pseudomonas aeruginosa via a Novel ISCR Element, ISCR5{triangledown}

Hongyang Li,1 Timothy R. Walsh,2 and Mark A. Toleman2*

Department of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, United Kingdom,1 Department of Medical Microbiology, School of Medicine, University of Cardiff, Cardiff CF14 4XN, United Kingdom2

Received 11 April 2008/ Returned for modification 6 July 2008/ Accepted 28 November 2008

The blaOXA-45 gene of Pseudomonas aeruginosa 07-406 is driven by a promoter found within a truncated ISPme1 insertion sequence. The gene is located between nonidentical repeats of a new ISCR element, ISCR5, which is likely responsible for its acquisition. Sequence analysis indicates that ISCR5 is a chimera of ISCR3 and ISCR16.

* Corresponding author. Mailing address: Department of Medical Microbiology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom. Phone: 44 (0) 29 2074 3129. Fax: 44 (0) 29 2074 2161. E-mail: TolemanMA{at}Cardiff.ac.uk

{triangledown} Published ahead of print on 8 December 2008.

Antimicrobial Agents and Chemotherapy, March 2009, p. 1248-1251, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.00480-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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