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Antimicrobial Agents and Chemotherapy, March 2009, p. 1278-1280, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.01519-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Oral and Parenteral Therapeutic Options for Outpatient Urinary Infections Caused by Enterobacteriaceae Producing CTX-M Extended-Spectrum β-Lactamases{triangledown}

Vidhya Prakash,1 James S. Lewis II,2 Monica L. Herrera,3 Brian L. Wickes,3 and James H. Jorgensen2,3,4*

San Antonio Military Medical Center, Infectious Disease Service, San Antonio, Texas 78234,1 Department of Medicine, The University of Texas Health Science Center and Pharmacy Service, University Hospital, San Antonio, Texas 78229,2 Department of Microbiology and Immunology, The University of Texas Health Science Center, San Antonio, Texas 78229,3 Department of Pathology, The University of Texas Health Science Center, San Antonio, Texas 782294

Received 13 November 2008/ Returned for modification 11 December 2008/ Accepted 26 December 2008

Effective therapeutic options are needed for community-onset urinary tract infections due to Escherichia coli strains that produce CTX-M extended-spectrum β-lactamases. We examined 46 urinary isolates producing CTX-M against several oral or long-acting parenteral antimicrobial agents. Approximately 90% were susceptible to fosfomycin and to a combination of cefdinir plus amoxicillin-clavulanate. All were susceptible to ertapenem.

* Corresponding author. Mailing address: Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900. Phone: (210) 567-4088. Fax: (210) 567-2367. E-mail: jorgensen{at}uthscsa.edu

{triangledown} Published ahead of print on 5 January 2009.

Antimicrobial Agents and Chemotherapy, March 2009, p. 1278-1280, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.01519-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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