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Antimicrobial Agents and Chemotherapy, April 2009, p. 1630-1635, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01431-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

blaCTX-M Genes in Escherichia coli Strains from Croatian Hospitals Are Located in New (blaCTX-M-3a) and Widely Spread (blaCTX-M-3a and blaCTX-M-15) Genetic Structures{triangledown}

Elzbieta Literacka,1 Branka Bedenic,2 Anna Baraniak,1 Janusz Fiett,1 Marija Tonkic,3 Ines Jajic-Bencic,4 and Marek Gniadkowski1*

National Medicines Institute, Warsaw, Poland,1 School of Medicine, University of Zagreb, and Clinical Hospital Center, Zagreb, Croatia,2 University Hospital, Split, Croatia,3 Sisters of Mercy University Hospital, Zagreb, Croatia4

Received 24 October 2008/ Returned for modification 28 December 2008/ Accepted 25 January 2009

CTX-M-producing Escherichia coli isolates from three Croatian hospitals were analyzed. All blaCTX-M-15 genes and one blaCTX-M-3a gene resided in widely spread ISEcp1 transposition modules, but other blaCTX-M-3a genes were in a new configuration with two IS26 copies, indicating a new event of gene mobilization from a Kluyvera ascorbata genome. The study confirmed the role of the E. coli ST131 clonal group with IncFII-type plasmids in the spread of blaCTX-M-15 and of IncL/M pCTX-M3-type plasmids in the dissemination of blaCTX-M-3a.

* Corresponding author. Mailing address: National Medicines Institute, ul. Chelmska 30/34, 00-725 Warsaw, Poland. Phone: (48) 22-851 43 88. Fax: (48) 22-841 29 49. E-mail: gniadkow{at}cls.edu.pl

{triangledown} Published ahead of print on 2 February 2009.

Antimicrobial Agents and Chemotherapy, April 2009, p. 1630-1635, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01431-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Hrabak, J., Empel, J., Bergerova, T., Fajfrlik, K., Urbaskova, P., Kern-Zdanowicz, I., Hryniewicz, W., Gniadkowski, M. (2009). International Clones of Klebsiella pneumoniae and Escherichia coli with Extended-Spectrum {beta}-Lactamases in a Czech Hospital. J. Clin. Microbiol. 47: 3353-3357 [Abstract] [Full Text]  
  • Pitout, J. D. D., Gregson, D. B., Campbell, L., Laupland, K. B. (2009). Molecular Characteristics of Extended-Spectrum-{beta}-Lactamase-Producing Escherichia coli Isolates Causing Bacteremia in the Calgary Health Region from 2000 to 2007: Emergence of Clone ST131 as a Cause of Community-Acquired Infections. Antimicrob. Agents Chemother. 53: 2846-2851 [Abstract] [Full Text]  
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