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Antimicrobial Agents and Chemotherapy, April 2009, p. 1636-1638, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.00697-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vitro Comparison of the Efficacies of Natamycin and Silver Nitrate against Ocular Fungi{triangledown}

Yan Xu,1* Guangren Pang,1 Chuanwen Gao,1 Dongqing Zhao,1 Lutan Zhou,1 Shengtao Sun,1 and Bingliang Wang2

Henan Institute of Ophthalmology, Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, China,1 Anyang Eye Hospital, Anyang, China2

Received 28 May 2008/ Returned for modification 4 September 2008/ Accepted 4 January 2009

The in vitro activity of the silver nitrate was assessed in comparison with that of natamycin against 128 corneal Fusarium isolates and 90 corneal Aspergillus isolates. MIC90s of silver nitrate were 2 µg/ml for Fusarium spp. and 1 µg/ml for Aspergillus spp. MIC90s of natamycin were 8 µg/ml for Fusarium spp. and 32 µg/ml for Aspergillus spp. Silver nitrate exhibited potent antifungal activity against ocular fungi in vitro.


* Corresponding author. Mailing address: Department of Ocular Pharmacology, Henan Institute of Ophthalmology, 7 Weiwu Road, Zhengzhou 450003, China. Phone: 0086-0371-65580918. Fax: 0086-0371-65580157. E-mail: xuyan990301{at}yahoo.com.cn

{triangledown} Published ahead of print on 12 January 2009.


Antimicrobial Agents and Chemotherapy, April 2009, p. 1636-1638, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.00697-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.