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Antimicrobial Agents and Chemotherapy, April 2009, p. 1639-1641, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.00955-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Activity of Anidulafungin in a Murine Model of Candida krusei Infection: Evaluation of Mortality and Disease Burden by Quantitative Tissue Cultures and Measurement of Serum (1,3)-β-D-Glucan Levels{triangledown}

Luis Ostrosky-Zeichner,1* Victor L. Paetznick,1 Jose Rodriguez,1 Enuo Chen,1 and Daniel J. Sheehan2

Laboratory of Mycology Research, University of Texas Medical School at Houston, Houston, Texas,1 Pfizer, Inc., New York, New York2

Received 18 July 2008/ Returned for modification 17 October 2008/ Accepted 6 January 2009

Experience with anidulafungin against Candida krusei is limited. Immunosuppressed mice were injected with 1.3 x 107 to 1.5 x 107 CFU of C. krusei. Animals were treated with saline, 40 mg/kg fluconazole, 1 mg/kg amphotericin B, or 10 and 20 mg/kg anidulafungin for 5 days. Anidulafungin improved survival and significantly reduced the number of CFU/g in kidneys and serum β-glucan levels.

* Corresponding author. Mailing address: Division of Infectious Diseases, University of Texas Medical School at Houston, 6431 Fannin, MSB 2.112, Houston, TX 77030. Phone: (713) 500-6733. Fax: (713) 500-5495. E-mail: Luis.Ostrosky-Zeichner{at}uth.tmc.edu

{triangledown} Published ahead of print on 12 January 2009.

Antimicrobial Agents and Chemotherapy, April 2009, p. 1639-1641, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.00955-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Canton, E., Peman, J., Valentin, A., Espinel-Ingroff, A., Gobernado, M. (2009). In Vitro Activities of Echinocandins against Candida krusei Determined by Three Methods: MIC and Minimal Fungicidal Concentration Measurements and Time-Kill Studies. Antimicrob. Agents Chemother. 53: 3108-3111 [Abstract] [Full Text]  


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