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Antimicrobial Agents and Chemotherapy, April 2009, p. 1642-1644, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01325-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Two Clinical Strains of Klebsiella pneumoniae Carrying Plasmid-Borne blaIMP-4, blaSHV-12, and armA Isolated at a Pediatric Center in Shanghai, China{triangledown}

Ying Liu,1 Bei Zhang,2 Qing Cao,2 Weichun Huang,2 Lisong Shen,1 and Xuan Qin3,4*

Clinical Laboratory Diagnostic Center, Xin Hua Hospital, Shanghai, China,1 Infectious Disease Department, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dong Fang Road, Shanghai 200127, China,2 Microbiology Laboratory, Seattle Children's Hospital, Seattle, Washington,3 Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington4

Received 2 October 2008/ Returned for modification 6 November 2008/ Accepted 10 January 2009

Two cases of pulmonary infection due to strains of multidrug-resistant Klebsiella pneumoniae were investigated. Beta-lactamase determinants, such as blaIMP-4 and blaSHV-12, and the 16S rRNA methyltransferase-encoding gene armA were detected in these plasmid-bearing organisms. The integron-borne blaIMP-4 and armA contained intervening sequences highly related to those of a Vibrio cholerae O139 plasmid found in Hangzhou, China.

* Corresponding author. Mailing address: Microbiology Laboratory, A6901, Seattle Children's Hospital, Seattle, Washington 98105. Phone: (206) 987-2586. Fax: (206) 987-3840. E-mail: xuan.qin{at}seattlechildrens.org

{triangledown} Published ahead of print on 21 January 2009.

Antimicrobial Agents and Chemotherapy, April 2009, p. 1642-1644, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01325-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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