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Antimicrobial Agents and Chemotherapy, April 2009, p. 1657-1659, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.00998-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Fluconazole and Voriconazole against Clinical Isolates of Candida spp. Determined by Disk Diffusion Testing in Turin, Italy{triangledown}

Narcisa Mandras,1 Vivian Tullio,1* Valeria Allizond,1 Daniela Scalas,1 Giuliana Banche,1 Janira Roana,1 Francesca Robbiano,2 Giacomo Fucale,3 Aurelio Malabaila,4 Anna Maria Cuffini,1 and Nicola Carlone1

Department of Public Health and Microbiology, University of Turin, Turin, Italy,1 Microbiology Laboratory, S. Giovanni Battista Hospital, Turin, Italy,2 Analysis Laboratory and Microbiology, C.T.O./C.R.F. Hospital, Turin, Italy,3 Analysis Laboratory and Microbiology, Infermi Hospital, Biella, Italy4

Received 25 July 2008/ Returned for modification 22 August 2008/ Accepted 23 January 2009

The in vitro activities of fluconazole and voriconazole against 1,024 clinical isolates of Candida spp. were determined by the agar disk diffusion test using the Clinical and Laboratory Standards Institute (CLSI) M44-A guidelines. The results of this investigation demonstrated the broad-spectrum in vitro activity of voriconazole, relative to that of fluconazole, against yeasts tested, in particular fluconazole-resistant isolates, such as Candida krusei that showed high susceptibility to voriconazole. The situation in Turin, Italy, is quite similar to that of the rest of Italy, reflecting the worldwide trend.

* Corresponding author. Mailing address: Department of Public Health and Microbiology, Microbiology Section, University of Turin, Via Santena 9, 10126 Turin, Italy. Phone: 390116705637. Fax: 390112365637. E-mail: vivian.tullio{at}unito.it

{triangledown} Published ahead of print on 2 February 2009.

Antimicrobial Agents and Chemotherapy, April 2009, p. 1657-1659, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.00998-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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