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Antimicrobial Agents and Chemotherapy, April 2009, p. 1665-1666, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01447-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Temporal Appearance of Plasmid-Mediated Quinolone Resistance Genes{triangledown}

George A. Jacoby,1* Nancy Gacharna,1 Todd A. Black,2 George H. Miller,3 and David C. Hooper4

Lahey Clinic, Burlington, Massachusetts,1 Schering-Plough Research Institute, Kenilworth, New Jersey,2 Blanca Pharmaceuticals, Menlo Park, California,3 Massachusetts General Hospital, Boston, Massachusetts4

Received 29 October 2008/ Returned for modification 19 December 2008/ Accepted 11 January 2009

One hundred fifty AAC(6')-Ib-positive gram-negative isolates collected between 1981 and 1991 were examined by PCR for the presence of the aac(6')-Ib-cr variant and other plasmid-mediated quinolone resistance (PMQR) genes. None had the aac(6')-Ib-cr variant, qnrA, qnrS, qnrC, or qepA, but two strains collected in 1988 had qnrB alleles, making these the earliest known PMQR genes.

* Corresponding author. Mailing address: 41 Mall Road, Burlington, MA 01805. Phone: (781) 744-2928. Fax: (781) 744-5486. E-mail: george.a.jacoby{at}lahey.org

{triangledown} Published ahead of print on 21 January 2009.

Antimicrobial Agents and Chemotherapy, April 2009, p. 1665-1666, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01447-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Strahilevitz, J., Jacoby, G. A., Hooper, D. C., Robicsek, A. (2009). Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat. Clin. Microbiol. Rev. 22: 664-689 [Abstract] [Full Text]  
  • Gunell, M., Hakanen, A. J., Jalava, J., Huovinen, P., Osterblad, M. (2009). Hidden qnrB12 gene in a Finnish faecal microbiota isolate from 1994. J Antimicrob Chemother 64: 861-862 [Full Text]  


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