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Antimicrobial Agents and Chemotherapy, April 2009, p. 1667-1669, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.00692-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Contribution of the Autolysin AtlA to the Bactericidal Activity of Amoxicillin against Enterococcus faecalis JH2-2{triangledown}

Anne-Lise Bravetti,1,2,3,4 Stéphane Mesnage,2,3,4 Agnès Lefort,1* Françoise Chau,1 Catherine Eckert,2,3,4 Louis Garry,5 Michel Arthur,2,3,4 and Bruno Fantin1

EA3964, Faculté de Médecine Xavier Bichat, Université Paris 7, Paris F-75018, France,1 Centre de Recherche des Cordeliers, Université Pierre et Marie Curie—Paris 6, UMRS 872, Paris F-75006, France,2 Université Paris Descartes—Paris 5, UMRS 872, Paris F-75006, France,3 INSERM, U872, Paris F-75006, France,4 INSERM, U722, Paris F-75018, France5

Received 27 May 2008/ Returned for modification 7 August 2008/ Accepted 21 January 2009

The bactericidal activity of amoxicillin was investigated against Enterococcus faecalis JH2-2 and against an isogenic mutant deficient in the production of the N-acetylglucosaminidase AtlA. Comparison of the two strains indicated that this autolysin contributes to killing by amoxicillin both in vitro and in a rabbit model of experimental endocarditis.

* Corresponding author. Present address: Service de Médecine Interne, Hôpital Beaujon, 100, Boulevard du Général Leclerc, 92110 Clichy, France. Phone: 33 1 40 87 52 27. Fax: 33 1 40 87 10 81. E-mail: aglefort{at}yahoo.com

{triangledown} Published ahead of print on 2 February 2009.

Antimicrobial Agents and Chemotherapy, April 2009, p. 1667-1669, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.00692-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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