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Antimicrobial Agents and Chemotherapy, April 2009, p. 1679-1682, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01334-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Radioimmunotherapy Is Effective against High-Inoculum Cryptococcus neoformans Infection in Mice and Does Not Select for Radiation-Resistant Cryptococcal Cells{triangledown}

Ruth A. Bryan,1 Zewei Jiang,1 Xianchun Huang,1 Alfred Morgenstern,2 Frank Bruchertseifer,2 Rani Sellers,3 Arturo Casadevall,4,5,# and Ekaterina Dadachova1,4*,#

Departments of Nuclear Medicine,1 Pathology,3 Microbiology and Immunology,4 Medicine, Albert Einstein College of Medicine, Bronx, New York,5 European Commission, Joint Research Centre, Institute for Transuranium Elements, Karlsruhe, Germany2

Received 5 October 2008/ Returned for modification 15 November 2008/ Accepted 31 December 2008

We investigated the utility of radioimmunotherapy (RIT) in the treatment of experimental cryptococcal infection with high-inoculum and the possibility of RIT treatment selecting for fungal cells with radiation-resistant phenotypes. RIT reduced mortality in high-burden infections, and we found no evidence for the development of radiation-resistant cells.

* Corresponding author. Mailing address: Albert Einstein College of Medicine, Department of Nuclear Medicine, 1695A Eastchester Rd., Bronx, NY 10461. Phone: (718) 405-8485. Fax: (718) 405-8457. E-mail: edadacho{at}aecom.yu.edu

{triangledown} Published ahead of print on 12 January 2009.

# E. Dadachova and A. Casadevall share the senior authorship of the paper.

Antimicrobial Agents and Chemotherapy, April 2009, p. 1679-1682, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01334-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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