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Antimicrobial Agents and Chemotherapy, April 2009, p. 1701-1704, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01309-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Transcriptional Signature following Inhibition of Early-Stage Cell Wall Biosynthesis in Staphylococcus aureus{triangledown}

A. J. O'Neill,1 J. A. Lindsay,2 K. Gould,2 J. Hinds,2 and I. Chopra1*

Antimicrobial Research Centre and Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom,1 Division of Cellular and Molecular Medicine, St. George's University of London, London SW17 0RE, United Kingdom2

Received 30 September 2008/ Returned for modification 19 December 2008/ Accepted 11 January 2009

To facilitate mode of action studies on antibacterial inhibitors of early-stage cell wall biosynthesis (CWB), we determined the transcriptional response of Staphylococcus aureus to depletion/inhibition of enzymes in this pathway by DNA microarray analysis. We identified a transcriptional signature distinct from that previously observed following exposure to inhibitors of late-stage CWB.

* Corresponding author. Mailing address: Antimicrobial Research Centre and Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom. Phone: 44 113 233 5604. Fax: 44 113 233 5638. E-mail: i.chopra{at}leeds.ac.uk

{triangledown} Published ahead of print on 21 January 2009.

Antimicrobial Agents and Chemotherapy, April 2009, p. 1701-1704, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01309-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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