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Antimicrobial Agents and Chemotherapy, May 2009, p. 2139-2141, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.00090-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Comparative In Vitro Susceptibilities of Human Mycoplasmas and Ureaplasmas to a New Investigational Ketolide, CEM-101 {triangledown}

Ken B. Waites,* D. M. Crabb, and Lynn B. Duffy

Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama

Received 21 January 2009/ Returned for modification 13 February 2009/ Accepted 17 February 2009

MICs were determined for an investigational ketolide, CEM-101, and azithromycin, telithromycin, doxycycline, levofloxacin, clindamycin, and linezolid against 36 Mycoplasma pneumoniae, 5 Mycoplasma genitalium, 13 Mycoplasma hominis, 15 Mycoplasma fermentans, and 20 Ureaplasma isolates. All isolates, including two macrolide-resistant M. pneumoniae isolates, were inhibited by CEM-101 at ≤0.5 µg/ml, making CEM-101 the most potent compound tested.

* Corresponding author. Mailing address: Department of Pathology, 619 19th Street South, WP 230, University of Alabama at Birmingham, Birmingham, AL 35249. Phone: (205) 934-4960. Fax: (205) 975-4468. E-mail: waiteskb{at}uab.edu

{triangledown} Published ahead of print on 2 March 2009.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2139-2141, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.00090-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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