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Antimicrobial Agents and Chemotherapy, May 2009, p. 2156-2157, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01125-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Pharmacokinetics of Intracameral Voriconazole Injection{triangledown}

Ying-Cheng Shen,1,2 Mei-Yen Wang,3 Chun-Yuan Wang,1,4 Tsun-Chung Tsai,3 Hin-Yeung Tsai,1,4 Hsin-Nung Lee,1 and Li-Chen Wei1,2*

Department of Ophthalmology, Taichung Veterans General Hospital, Taiwan, Republic of China,1 Overseas Chinese Institute of Technology, Taichung, Taiwan, Republic of China,2 Department of Food Science, Tunghai University, Taiwan, Republic of China,3 Hung Kuang University, Taiwan, Republic of China4

Received 22 August 2008/ Returned for modification 28 January 2009/ Accepted 9 February 2009

Elimination of voriconazole after intracameral injection exhibited an exponential decay with a half-life of 22 min. Voriconazole levels in the vitreous humor were below the detectable limit. The aqueous concentrations achieved with a 25-µg dose during the first 2 h were greater than the previously reported MICs of organisms most involved in fungal endophthalmitis. A rapid decline in intracameral concentration suggests that frequent supplementation of intracameral voriconazole may be required in clinical settings.

* Corresponding author. Mailing address: Department of Ophthalmology, Taichung Veterans General Hospital, No. 160, Section 3, Taichung Harbor Road, Taichung, Taiwan, Republic of China. Phone: 886-4-23592525, ext. 4212. Fax: 886-4-23591607. E-mail: eric550131{at}yahoo.com.tw

{triangledown} Published ahead of print on 2 March 2009.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2156-2157, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01125-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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