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Antimicrobial Agents and Chemotherapy, May 2009, p. 2160-2162, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01684-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Antimicrobial Susceptibility of Mycoplasma pneumoniae Isolates and Molecular Analysis of Macrolide-Resistant Strains from Shanghai, China {triangledown}

Yang Liu,1 Xinyu Ye,1 Hong Zhang,2 Xiaogang Xu,1 Wanhua Li,2 Demei Zhu,1 and Minggui Wang1,3*

Institute of Antibiotics, Huashan Hospital,1 Institute of Biomedical Sciences, Fudan University, Shanghai 200040, China,3 Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai 200040, China2

Received 20 December 2008/ Returned for modification 27 January 2009/ Accepted 22 February 2009

Fifty-three Mycoplasma pneumoniae strains were isolated from pediatric patients in Shanghai, China, from October 2005 to February 2008. Of 53 clinical isolates, 44 (83%) were resistant to erythromycin (MICs of >128 µg/ml for all 44 strains), azithromycin, and clarithromycin. All macrolide-resistant M. pneumoniae strains harbored an A-to-G transition mutation at position 2063 in 23S rRNA genes. Forty-five (85%) clinical isolates were classified into the P1 gene restriction fragment length polymorphism type I, and six (11%) were type II.

* Corresponding author. Mailing address: Institute of Antibiotics, Huashan Hospital, Fudan University, 12 M. Wulumuqi Rd., Shanghai 200040, People's Republic of China. Phone: (86-21) 52888195. Fax: (86-21) 62482859. E-mail: mgwang{at}fudan.edu.cn

{triangledown} Published ahead of print on 9 March 2009.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2160-2162, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01684-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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