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Antimicrobial Agents and Chemotherapy, May 2009, p. 2189-2191, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01091-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Early Postpartum Pharmacokinetics of Lopinavir Initiated Intrapartum in Thai Women {triangledown} ,{dagger}

Tim R. Cressey,1,3* Russell Van Dyke,2 Gonzague Jourdain,1,3 Thanyawee Puthanakit,4 Anuvat Roongpisuthipong,5 Jullapong Achalapong,6 Prapap Yuthavisuthi,7 Sinart Prommas,8 Nantasak Chotivanich,9 Robert Maupin,10 Elizabeth Smith,11 David E. Shapiro,1 Mark Mirochnick,12 for the IMPAACT P1032 Team

Harvard School of Public Health, Boston, Massachusetts,1 Tulane University, New Orleans, Louisiana,2 Institut de Recherche pour le Développement (IRD), PHPT-IRD174, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand,3 Research Institute Health Sciences, Chiang Mai University, Chiang Mai, Thailand,4 Siriraj Hospital, Bangkok, Thailand,5 Chiang Rai Prachanukoh Hospital, Chiang Rai, Thailand,6 Prapokklao Hospital, Chantaburi, Thailand,7 Bhumibol Adulyadej Hospital, Bangkok, Thailand,8 Chonburi Hospital, Chonburi, Thailand,9 Louisiana State University, New Orleans, Louisiana,10 Pediatric Medicine Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland,11 Boston University Medical School, Boston, Massachusetts,12

Received 13 August 2008/ Returned for modification 20 January 2009/ Accepted 9 February 2009

Lopinavir (LPV) exposure is reduced during the third trimester of pregnancy. We report the pharmacokinetics of standard LPV-ritonavir dosing (400/100 mg twice daily) in the immediate and early postpartum period when initiated during labor. In 16 human immunodeficiency virus-infected Thai women, the median (range) LPV area under the concentration-time curve and maximum and minimum concentrations in plasma were 99.7 (66.1 to 180.5) µg·h/ml, 11.2 (8.0 to 17.5) µg/ml, and 4.6 (1.7 to 12.5) µg/ml, respectively, at 41 (12 to 74) h after delivery. All of the women attained adequate LPV levels through 30 days postpartum. No serious adverse events were reported.

* Corresponding author. Mailing address: Program for HIV Prevention and Treatment (PHPT-IRD174), 29/7-8 Samlan Road, Soi 1 Prasing, Muang, Chiang Mai 50205, Thailand. Phone: 66 5381 4270. Fax: 66 5381 4269. E-mail: tim{at}phpt.org

{triangledown} Published ahead of print on 23 February 2009.

{dagger} Substudy of the International Maternal Pediatric Adolescent AIDS Clinical Trial (IMPAACT) group P1032 study.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2189-2191, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01091-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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