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Antimicrobial Agents and Chemotherapy, May 2009, p. 2199-2201, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01492-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Avian Aspergillus fumigatus Strains Resistant to both Itraconazole and Voriconazole{triangledown}

L. A. Beernaert,1* F. Pasmans,1 L. Van Waeyenberghe,1 G. M. Dorrestein,2 F. Verstappen,3 F. Vercammen,4 F. Haesebrouck,1 and A. Martel1

Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisuburylaan 133, Merelbeke, Belgium,1 Diagnostic Pathology Laboratory, Dutch Research Institute for Birds and Exotic Animals (NOIVBD), Wintelresedijk 51, Veldhoven, The Netherlands,2 Veterinary Clinic Hoofdstraat, Hoofdstraat 121, Driebergen, the Netherlands,3 Antwerp Zoo, Koningin Astridplein 26, Antwerp, Belgium4

Received 7 November 2008/ Returned for modification 12 December 2008/ Accepted 19 February 2009

The in vitro susceptibilities of 59 avian Aspergillus fumigatus strains to amphotericin B, itraconazole, and voriconazole were determined using the standard microdilution broth method (CLSI M38-A2). Four isolates showed acquired resistance to itraconazole and voriconazole, harboring implications for the treatment of aspergillosis in both birds and humans.

* Corresponding author. Mailing address: Faculty of Veterinary Medicine, UGent, Salisburylaan 133, 9820 Merelbeke, Belgium. Phone: 32 9 264 7442. Fax: 32 9 264 7490. E-mail: lies.beernaert{at}ugent.be

{triangledown} Published ahead of print on 2 March 2009.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2199-2201, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01492-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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