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Antimicrobial Agents and Chemotherapy, May 2009, p. 2202-2204, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01085-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Tolevamer Is Not Efficacious in the Neutralization of Cytotoxin in a Human Gut Model of Clostridium difficile Infection {triangledown}

Simon D. Baines,1 Jane Freeman,2 and Mark H. Wilcox1,2*

Department of Microbiology, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom,1 Department of Microbiology, The General Infirmary, Old Medical School, Leeds LS1 3EX, United Kingdom2

Received 12 August 2008/ Returned for modification 7 October 2008/ Accepted 30 January 2009

The efficacy of tolevamer, a nonantimicrobial styrene derivative toxin-binding agent, in treating simulated Clostridium difficile infection in an in vitro human gut model was investigated. Tolevamer reduced neither the duration nor magnitude of cytotoxin activity by C. difficile, reflecting poor efficacy observed in recent phase III clinical trials.

* Corresponding author. Mailing address: Microbiology, The General Infirmary, Old Medical School, Leeds LS1 3EX, United Kingdom. Phone: 44 113 3926818. Fax: 44 113 3435649. E-mail: mark.wilcox{at}leedsth.nhs.uk

{triangledown} Published ahead of print on 17 February 2009.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2202-2204, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01085-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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