This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental material
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lorenzi, V.
Right arrow Articles by Bolla, J.-M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lorenzi, V.
Right arrow Articles by Bolla, J.-M.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, May 2009, p. 2209-2211, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.00919-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Geraniol Restores Antibiotic Activities against Multidrug-Resistant Isolates from Gram-Negative Species{triangledown} ,{dagger}

Vannina Lorenzi,1,§ Alain Muselli,2 Antoine François Bernardini,2 Liliane Berti,3 Jean-Marie Pagès,1 Leonard Amaral,4 and Jean-Michel Bolla1*

Université de la Méditerranée, UMR-MD1, IFR88, Faculté de Médecine, 13385 Marseille Cedex 05, France,1 Université de Corse, Equipe Chimie des Produits Naturels, UMR-CNRS 6134, Quartier Grossetti, BP 52, 20250 Corte, France,2 Université de Corse, Laboratoire de Biochimie et de Biologie Moléculaire du Végétal, UMR-CNRS 6134, Quartier Grossetti, BP 52, 20250 Corte, France,3 Unit of Mycobacteriology, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Lisbon, Portugal4

Received 11 July 2008/ Returned for modification 5 September 2008/ Accepted 16 February 2009

The essential oil of Helichrysum italicum significantly reduces the multidrug resistance of Enterobacter aerogenes, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii. Combinations of the two most active fractions of the essential oil with each other or with phenylalanine arginine β-naphthylamide yield synergistic activity. Geraniol, a component of one fraction, significantly increased the efficacy of β-lactams, quinolones, and chloramphenicol.

* Corresponding author. Mailing address: UMR-MD1, Faculté de Médecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France. Phone: (33) 4 91 32 44 40. Fax: (33) 4 91 32 46 06. E-mail: Jean-Michel.Bolla{at}medecine.univ-mrs.fr

{triangledown} Published ahead of print on 2 March 2009.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

§ Present address: Université de Corse, Laboratoire de Biochimie et de Biologie Moléculaire du Végétal, UMR-CNRS 6134, Quartier Grossetti, BP 52, 20250 Corte, France.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2209-2211, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.00919-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»