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Antimicrobial Agents and Chemotherapy, May 2009, p. 2215-2217, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01100-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Antibacterial Activity of Ultrashort Cationic Lipo-β-Peptides{triangledown}

Griselda N. Serrano,1 George G. Zhanel,2 and Frank Schweizer1,2*

Department of Chemistry, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada,1 Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3A 1R9, Canada2

Received 15 August 2008/ Returned for modification 12 November 2008/ Accepted 10 February 2009

Previously reported D,L-lipo-{alpha}-peptides and their lipo-β-peptide counterparts (C16-KGGK, C16-KAAK, C16-KKKK, and C12-KLLK) were studied, and the lipo-β-peptides were found to retain antimicrobial activity. Likewise, no significant changes in antimicrobial activity were found upon activity comparisons with D,L-amino acid-based lipopeptides or any L-amino acid lipopeptides. As a defined amphipathic structure is unlikely to form with such short molecules and as similar activities were obtained from all lipopeptides, we suspect that the action of membrane permeation is retained.

* Corresponding author. Mailing address: University of Manitoba, 144 Dysart Rd., Winnipeg, Manitoba R3T 2N2, Canada. Phone: (204) 474-7012. Fax: (204) 474-7608. E-mail: schweize{at}cc.umanitoba.ca

{triangledown} Published ahead of print on 23 February 2009.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2215-2217, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01100-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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