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Antimicrobial Agents and Chemotherapy, May 2009, p. 2218-2220, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.00829-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Triple Combinations of Lower and Longer Alkyl Gallates and Oxacillin Improve Antibiotic Synergy against Methicillin-Resistant Staphylococcus aureus{triangledown}

Hirofumi Shibata,1 Tatsuro Nakano,1 M. Anowar Khasru Parvez,1 Yoshihiro Furukawa,1 Akio Tomoishi,1 Shingo Niimi,2 Naokatu Arakaki,1 and Tomihiko Higuti1*

Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 1-78 Sho-machi, Tokushima 770-8505, Japan,1 Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, Kamiyoga, Tokyo 158-8501, Japan2

Received 24 June 2008/ Returned for modification 22 October 2008/ Accepted 2 February 2009

Using liposome systems, we found that gallates with short alkyl chains were located in the external medium and those with longer alkyl chains were located in the surface region of lipid bilayer. Combinations of these gallates remarkably reduced oxacillin MICs against methicillin-resistant Staphylococcus aureus to below the antibiotic breakpoint (≤2 µg/ml).

* Corresponding author. Mailing address: Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 1-78 Sho-machi, Tokushima 770-8505, Japan. Phone: 81-88-633-7254. Fax: 81-88-633-9550. E-mail: higuchi{at}mibct.com

{triangledown} Published ahead of print on 17 February 2009.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2218-2220, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.00829-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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