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Antimicrobial Agents and Chemotherapy, June 2009, p. 2626-2628, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01101-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Comparative Efficacies of Telavancin and Vancomycin in Preventing Device-Associated Colonization and Infection by Staphylococcus aureus in Rabbits{triangledown}

Rabih O. Darouiche,1* Mohammad D. Mansouri,1 and Marlowe J. Schneidkraut2

Infectious Disease Section and Center for Prostheses Infection, Michael E. Debakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas,1 Astellas Pharma US, Inc., Deerfield, Illinois2

Received 16 August 2008/ Returned for modification 19 January 2009/ Accepted 27 March 2009

Telavancin is an investigational lipoglycopeptide antibiotic that is active against gram-positive pathogens. In an in vivo rabbit model, subtherapeutic (15-mg/kg) and therapeutic (30- or 45-mg/kg) doses of telavancin were demonstrated to be noninferior and superior to vancomycin (20 mg/kg), respectively, for preventing subcutaneous implant colonization and infection by Staphylococcus aureus.

* Corresponding author. Mailing address: Center for Prostheses Infection, Baylor College of Medicine, 1333 Moursund Avenue, Suite A221, Houston, TX 77030. Phone: (713) 799-5088. Fax: (713) 799-5058. E-mail: rdarouiche{at}aol.com

{triangledown} Published ahead of print on 13 April 2009.

Antimicrobial Agents and Chemotherapy, June 2009, p. 2626-2628, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01101-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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