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Antimicrobial Agents and Chemotherapy, June 2009, p. 2632-2635, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01722-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

High Prevalence of qnr Genes in Commensal Enterobacteria from Healthy Children in Peru and Bolivia{triangledown} ,{dagger}

Lucia Pallecchi,1 Eleonora Riccobono,1 Antonia Mantella,2 Filippo Bartalesi,2 Samanta Sennati,1 Herlan Gamboa,3 Eduardo Gotuzzo,4 Alessandro Bartoloni,2 and Gian Maria Rossolini1,5*

Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena,1 Dipartimento dei Servizi, U. O. Microbiologia e Virologia, Azienda Ospedaliera-Universitaria Senese, Siena, Italy,5 Dipartimento Area Critica Medico Chirurgica, Clinica Malattie Infettive, Università di Firenze, Florence, Italy,2 Distrito de Salud Cordillera, Departamento Santa Cruz, Camiri, Bolivia,3 Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru4

Received 30 December 2008/ Returned for modification 27 January 2009/ Accepted 29 March 2009

A remarkable prevalence of qnrB (54%) and, at a lower level, of qnrS (14%) was discovered in pools of commensal enterobacteria from 310 healthy children living in Peru and Bolivia, using a metagenomic approach. Analysis of randomly selected enterobacterial pools revealed that qnrB was mainly carried by Escherichia coli and qnrS by Klebsiella pneumoniae. Investigation of 11 qnrB-positive isolates and 9 qnrS-positive isolates revealed the presence of plasmid-borne qnrB19 (n = 8), qnrB2 (n = 2), qnrB10 (n = 1), and qnrS1 (n = 9) genes.

* Corresponding author. Mailing address: Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, Policlinico Santa Maria alle Scotte, 53100 Siena, Italy. Phone: 39 0577 233455. Fax: 39 0577 233870. E-mail: rossolini{at}unisi.it

{triangledown} Published ahead of print on 13 April 2009.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, June 2009, p. 2632-2635, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01722-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



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  • Gunell, M., Hakanen, A. J., Jalava, J., Huovinen, P., Osterblad, M. (2009). Hidden qnrB12 gene in a Finnish faecal microbiota isolate from 1994. J Antimicrob Chemother 64: 861-862 [Full Text]  


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