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Antimicrobial Agents and Chemotherapy, June 2009, p. 2636-2637, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01415-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Regulation of mprF in Daptomycin-Nonsusceptible Staphylococcus aureus Strains{triangledown}

Soo-Jin Yang,1* Yan Q. Xiong,1,2,3 Paul M. Dunman,4 Jacques Schrenzel,5 Patrice François,5 Andreas Peschel,6 and Arnold S. Bayer1,2,3

Los Angeles Biomedical Research Institute, Torrance, California,1 Department of Medicine, Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, California,2 Geffen School of Medicine at UCLA, Los Angeles, California,3 Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska,4 Department of Internal Medicine, University Hospitals, Geneva, Switzerland,5 Cellular and Molecular Microbiology, Medical Microbiology and Hygiene, University of Tübingen, Germany6

Received 21 October 2008/ Returned for modification 24 January 2009/ Accepted 7 March 2009

We used a well-characterized isogenic set of clinical bloodstream Staphylococcus aureus strains to study (i) regulation of mprF-mediated phosphatidylglycerol lysinylation in the contexts of in vitro daptomycin (DAP) nonsuceptibility and (ii) the role of mprF mutation in endovascular virulence. We observed a correlation between increased expression of a mutant mprF gene and reduced in vitro DAP susceptibility. There were no detectable fitness differences between strains in experimental infective endocarditis.

* Corresponding author. Mailing address: LA Biomedical Research Institute at Harbor-UCLA, 1124 West Carson Street, RB-2, Rm 230, Torrance, CA 90502. Phone: (310) 222-6423. Fax: (310) 782-2016. E-mail: sjyang{at}labiomed.org

{triangledown} Published ahead of print on 16 March 2009.

Antimicrobial Agents and Chemotherapy, June 2009, p. 2636-2637, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01415-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



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