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Antimicrobial Agents and Chemotherapy, June 2009, p. 2646-2649, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01474-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Intracellular Localization of the ABCC Proteins of Leishmania and Their Role in Resistance to Antimonials{triangledown}

Philippe Leprohon, Danielle Légaré, and Marc Ouellette*

Centre de Recherche en Infectiologie et Division de Microbiologie, Université Laval, Québec, Canada G1V 4G2

Received 4 November 2008/ Returned for modification 15 January 2009/ Accepted 14 March 2009

The ABCC subfamily of proteins is composed of nine members in Leishmania. We report that all of these proteins have an intracellular localization and that the overexpression of at least four members, ABCC3, ABCC4, ABCC5, and ABCC7, can confer resistance to antimonials, the first-line drug against Leishmania.

* Corresponding author. Mailing address: Centre de Recherche en Infectiologie, 2705 Boul. Laurier, Québec, Canada G1V 4G2. Phone: (418) 654-2705. Fax: (418) 654-2715. E-mail: Marc.Ouellette{at}crchul.ulaval.ca

{triangledown} Published ahead of print on 23 March 2009.

Antimicrobial Agents and Chemotherapy, June 2009, p. 2646-2649, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01474-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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