This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Murayama, S. Y.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Murayama, S. Y.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, June 2009, p. 2650-2653, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01716-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Capsular Type and Antibiotic Resistance in Streptococcus agalactiae Isolates from Patients, Ranging from Newborns to the Elderly, with Invasive Infections{triangledown}

Somay Yamagata Murayama,1 Chizuko Seki,1 Hiroshi Sakata,2 Katsuhiko Sunaoshi,1 Eiichi Nakayama,1 Satoshi Iwata,3 Keisuke Sunakawa,4 Kimiko Ubukata,1* and the Invasive Streptococcal Disease Working Group

Laboratory of Molecular Epidemiology for Infectious Agents, Graduate School of Infection Control Sciences & Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan,1 Department of Pediatrics, Asahikawa-Kosei General Hospital, 1-24 Asahikawa City, Hokkaido 078-8211, Japan,2 Department of Pediatrics, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan,3 Laboratory of Infectious Diseases, Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan4

Received 25 December 2008/ Returned for modification 15 February 2009/ Accepted 21 March 2009

Streptococcus agalactiae isolates (n = 189) from patients with invasive infections were analyzed for capsular type by PCR, for antimicrobial susceptibility, and for the presence of resistance genes. In contrast to the predominance of capsular type III in children, types Ib and V were most common among adults. All 45 levofloxacin-resistant strains had two amino acid substitutions, Ser81Leu in the gyrA gene and Ser79Phe in the parC gene, and showed similar pulsed-field gel electrophoresis patterns.

* Corresponding author. Mailing address: Laboratory of Molecular Epidemiology for Infectious Agents, Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. Phone: 81-3-5791-6385. Fax: 81-3-5791-6386. E-mail: ubukatak{at}lisci.kitasato-u.ac.jp

{triangledown} Published ahead of print on 30 March 2009.

Antimicrobial Agents and Chemotherapy, June 2009, p. 2650-2653, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01716-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»