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Antimicrobial Agents and Chemotherapy, June 2009, p. 2654-2656, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01547-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Antifungal Activities of Natural and Synthetic Iron Chelators Alone and in Combination with Azole and Polyene Antibiotics against Aspergillus fumigatus{triangledown}

Kol A. Zarember,1*,{dagger} Anna R. Cruz,1,{dagger} Chiung-Yu Huang,2 and John I. Gallin1

Laboratory of Host Defenses,1 Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland2

Received 19 November 2008/ Returned for modification 30 December 2008/ Accepted 13 March 2009

Antifungal effects of iron chelators (lactoferrin, deferoxamine, deferiprone, and ciclopirox) were tested alone and in combination with antifungal drugs against Aspergillus fumigatus B5233 conidia. Lactoferrin, ciclopirox, and deferiprone inhibited whereas deferoxamine enhanced fungal growth. Antifungal synergy against conidia was observed for combinations of ketoconazole with ciclopirox or deferiprone, lactoferrin with amphotericin B, and fluconazole with deferiprone. Iron chelation alone or combined with antifungal drugs may be useful for prevention and treatment of mycosis.

* Corresponding author. Mailing address: Laboratory of Host Defenses, 10 Center Drive, RM 5W-3816, MSC 1456, Bethesda, MD 20892-1456. Phone: (301) 402-1802. Fax: (301) 402-0789. E-mail: kzarember{at}niaid.nih.gov

{triangledown} Published ahead of print on 23 March 2009.

{dagger} These authors contributed equally to the work.

Antimicrobial Agents and Chemotherapy, June 2009, p. 2654-2656, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01547-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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