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Antimicrobial Agents and Chemotherapy, June 2009, p. 2657-2659, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01663-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vivo Selection of Reduced Susceptibility to Carbapenems in Acinetobacter baumannii Related to ISAba1-Mediated Overexpression of the Natural blaOXA-66 Oxacillinase Gene{triangledown}

Samy Figueiredo,1 Laurent Poirel,1 Jacques Croize,2 Christine Recule,2 and Patrice Nordmann1*

Service de Bactériologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, K.-Bicêtre, France,1 Département de Bactériologie-Microbiovigilance, DAI Pôle de Biologie, Grenoble, France2

Received 18 December 2008/ Returned for modification 1 March 2009/ Accepted 15 March 2009

Two clonally related Acinetobacter baumannii isolates, A1 and A2, were obtained from the same patient. Isolate A2, selected after an imipenem-containing treatment, showed reduced susceptibility to carbapenems. This resistance pattern was related to insertion of the ISAba1 element upstream of the naturally occurring blaOXA-66 carbapenemase gene as demonstrated by sequencing, reverse transcription-PCR analysis, and inactivation of the blaOXA-66 gene.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 Rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.aphp.fr

{triangledown} Published ahead of print on 23 March 2009.

Antimicrobial Agents and Chemotherapy, June 2009, p. 2657-2659, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01663-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Figueiredo, S., Poirel, L., Papa, A., Koulourida, V., Nordmann, P. (2009). Overexpression of the Naturally Occurring blaOXA-51 Gene in Acinetobacter baumannii Mediated by Novel Insertion Sequence ISAba9. Antimicrob. Agents Chemother. 53: 4045-4047 [Full Text]  


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