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Antimicrobial Agents and Chemotherapy, June 2009, p. 2677-2678, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01514-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Gene Context and DNA Rearrangements in the Carbapenemase Locus of Division II Strains of Bacteroides fragilis{triangledown}

Nuria García,2 Gloria Gutiérrez,1 María Lorenzo,2 Santiago Vadillo,2 Segundo Píriz,2 and Alberto Quesada1*

Departamento de Bioquímica,1 Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de Extremadura, Avenida de la Universidad s/n, 10071-Cáceres, Spain2

Received 12 November 2008/ Returned for modification 20 February 2009/ Accepted 2 April 2009

The cfiA gene is clustered in a bicistronic operon encoding an N-acetyltransferase and an O-acetyltransferase related to resistance markers. This genetic context, exclusively found in strains of Bacteroides fragilis division II, has been highly rearranged by the successive integration of two new mobile sequences, a miniature element and ISBf9. Besides that, among the DNA polymorphisms detected in the cfiA locus, only the integration of IS942 at its promoter was a determinant for expression of carbapenemase activity.

* Corresponding author. Mailing address: Departamento de Bioquímica, Facultad de Veterinaria, Universidad de Extremadura, Avenida de la Universidad s/n, 10071-Cáceres, Spain. Phone: 34-927-257000-1334. Fax: 34-927257110. E-mail: aquesada{at}unex.es

{triangledown} Published ahead of print on 13 April 2009.

Antimicrobial Agents and Chemotherapy, June 2009, p. 2677-2678, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01514-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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