This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Joukhadar, C.
Right arrow Articles by Traunmüller, F.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Joukhadar, C.
Right arrow Articles by Traunmüller, F.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, June 2009, p. 2684-2686, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.00885-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Concentrations of Voriconazole in Healthy and Inflamed Lung in Rats{triangledown}

Christian Joukhadar,1,7* Christiane Thallinger,2,3 Wolfgang Pöppl,4 Florian Kovar,5 Karl H. Konz,6 Samir M. Joukhadar,4 and Friederike Traunmüller2,4

Beth Israel Deaconess Medical Center, Boston, Massachusetts,1 Department of Dermatology, Medical University of Innsbruck, Innsbruck, Austria,2 Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria,3 J&P Medical Research Ltd., Vienna, Austria,4 Department of Traumatology, Medical University of Vienna, Vienna, Austria,5 Department of Angiology and Diabetology, Hospital St. Kamillus der Kliniken Maria Hilf, Mönchengladbach, Germany,6 Harvard Medical School, Boston, Massachusetts7

Received 4 July 2008/ Returned for modification 21 September 2008/ Accepted 20 March 2009

By utilizing the microdialysis technique, we investigated the pharmacokinetic profile of voriconazole in the interstitium of the lungs and skeletal muscle tissue of rats after a single intravenous dose under healthy and inflammatory conditions. As expected, voriconazole penetrated excellently into the interstitium of tissues, and its levels were descriptively almost identical to free concentration-versus-time profiles in plasma.

* Corresponding author. Present address: Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215. Phone: 43 1 876 04 3210. Fax: 43 1 876 04 3233. E-mail: christian.joukhadar{at}jp-medical-research.com

{triangledown} Published ahead of print on 30 March 2009.

Antimicrobial Agents and Chemotherapy, June 2009, p. 2684-2686, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.00885-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»