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Antimicrobial Agents and Chemotherapy, June 2009, p. 2690-2692, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01424-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Bacteriostatic and Bactericidal Activities of Tigecycline against Coxiella burnetii and Comparison with Those of Six Other Antibiotics{triangledown}

Ioanna Spyridaki,* Anna Psaroulaki, Iosif Vranakis, Yannis Tselentis, and Achilleas Gikas

Department of Bacteriology, Parasitology, Zoonoses and Geographical Medicine, Faculty of Medicine, University of Crete, P.O. Box 1393, Heraklion, Crete, Greece

Received 23 October 2008/ Returned for modification 15 February 2009/ Accepted 21 March 2009

The present article is a study of the in vitro susceptibility of eight Greek Coxiella burnetii isolates, derived from patients with acute Q fever, and two reference strains of Coxiella burnetii to tigecycline. The bacteriostatic activity of tigecycline was compared with those of six other antibiotics using a shell vial assay. The MICs of the examined antibiotics were as follows: tigecycline ranged from 0.25 to 0.5 µg/ml; doxycycline, trovafloxacin, and ofloxacin ranged from 1 to 2 µg/ml; linezolid and clarithromycin ranged from 2 to 4 µg/ml; and ciprofloxacin ranged from 4 to 8 µg/ml. Tigecycline was effective in inhibiting the infection of Vero cells by C. burnetii. No bactericidal activity was observed against C. burnetii at 4 µg/ml.

* Corresponding author. Mailing address: University of Crete, School of Health Sciences, Division of Medicine, P.O. Box 1393, Heraklion, Crete, Greece. Phone: 30-2810-394625. Fax: 30-2810-394740. E-mail: ispyridaki{at}med.uoc.gr

{triangledown} Published ahead of print on 30 March 2009.

Antimicrobial Agents and Chemotherapy, June 2009, p. 2690-2692, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01424-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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