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Antimicrobial Agents and Chemotherapy, June 2009, p. 2693-2695, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01405-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Tetracycline Susceptibility Testing and Resistance Genes in Isolates of Acinetobacter baumannii-Acinetobacter calcoaceticus Complex from a U.S. Military Hospital{triangledown}

Kevin S. Akers,1 Katrin Mende,3 Heather C. Yun,1,2 Duane R. Hospenthal,1,2 Miriam L. Beckius,1 Xin Yu,1 and Clinton K. Murray1,2*

San Antonio Military Medical Center, Fort Sam Houston, Texas,1 Uniformed Services University of the Health Sciences, Bethesda, Maryland,2 Infectious Disease Clinical Research Program, San Antonio, Texas3

Received 20 October 2008/ Returned for modification 1 December 2008/ Accepted 14 March 2009

Infections with multidrug-resistant Acinetobacter baumannii-Acinetobacter calcoaceticus complex bacteria complicate the care of U.S. military personnel and civilians worldwide. One hundred thirty-three isolates from 89 patients at our facility during 2006 and 2007 were tested by disk diffusion, Etest, and broth microdilution for susceptibility to tetracycline, doxycycline, minocycline, and tigecycline. Minocycline was the most active in vitro, with 90% of the isolates tested susceptible. Susceptibilities varied significantly with the testing method. The acquired tetracycline resistance genes tetA, tetB, and tetA(39) were present in the isolates.

* Corresponding author. Mailing address: Infectious Disease Service, San Antonio Military Medical Center, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234. Phone: (210) 916-8752. Fax: (210) 916-0388. E-mail: Clinton.Murray{at}amedd.army.mil

{triangledown} Published ahead of print on 23 March 2009.

Antimicrobial Agents and Chemotherapy, June 2009, p. 2693-2695, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01405-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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