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Antimicrobial Agents and Chemotherapy, July 2009, p. 3103-3105, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.00019-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Lon Protease Is Essential for Paradoxical Survival of Escherichia coli Exposed to High Concentrations of Quinolone {triangledown}

Muhammad Malik, Joseph Capecci, and Karl Drlica*

Public Health Research Institute, New Jersey Medical School, UMDNJ, 225 Warren Street, Newark, New Jersey 07103

Received 6 January 2009/ Returned for modification 21 March 2009/ Accepted 29 April 2009

A deficiency of the Escherichia coli Lon protease blocked paradoxical survival occurring at very high nalidixic acid concentrations. The absence of Lon also blocked a parallel increase in cell lysate viscosity likely to reflect DNA size. Thus, Lon may participate in repairing quinolone-mediated DNA lesions formed at high drug concentrations.

* Corresponding author. Mailing address: Public Health Research Institute, New Jersey Medical School, UMDNJ, 225 Warren Street, Newark, NJ 07103. Phone: (973) 854-3360. Fax: (973) 854-3101. E-mail: drlicaka{at}umdnj.edu

{triangledown} Published ahead of print on 4 May 2009.

Antimicrobial Agents and Chemotherapy, July 2009, p. 3103-3105, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.00019-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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