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Antimicrobial Agents and Chemotherapy, July 2009, p. 3106-3107, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.01490-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vitro Elution of Daptomycin by a Synthetic Crystallic Semihydrate Form of Calcium Sulfate, Stimulan{triangledown}

Kyriaki Kanellakopoulou,1 Periklis Panagopoulos,1 Efthymia Giannitsioti,1 Thomas Tsaganos,1 Dionyssia-Pinelopi Carrer,1 Nicolas Efstathopoulos,2 and Evangelos J. Giamarellos-Bourboulis1*

4th Department of Internal Medicine,1 2nd Department of Orthopaedics, Medical School, University of Athens, Athens, Greece2

Received 7 November 2008/ Returned for modification 28 March 2009/ Accepted 17 April 2009

A synthetic crystallic semihydrate form of calcium sulfate, Stimulan, was evaluated as a biodegradable carrier for the daily in vitro elution of daptomycin. Daptomycin and Stimulan were admixed at a ratio of 95:5. Elution lasted for 28 days. Eluted concentrations peaked on days 1 and 11, when the mean values were 1,320.1 and 949.2 µg/ml, respectively. The lowest eluted concentration was detected on day 28. These results support the application of the system described in experimental models of osteomyelitis.

* Corresponding author. Mailing address: 4th Department of Internal Medicine, ATTIKON University Hospital, 1 Rimini Str., 124 62 Athens, Greece. Phone: 30 210 58 31 994. Fax: 30 210 53 26 446. E-mail: giamarel{at}ath.forthnet.gr

{triangledown} Published ahead of print on 27 April 2009.

Antimicrobial Agents and Chemotherapy, July 2009, p. 3106-3107, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.01490-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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