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Antimicrobial Agents and Chemotherapy, July 2009, p. 3131-3134, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.01689-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vitro Chemosensitization of Plasmodium falciparum to Antimalarials by Verapamil and Probenecid{triangledown}

Victor Masseno,1 Steven Muriithi,1 and Alexis Nzila1,2*

Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program, P.O. Box 230, 80108, Kilifi, Kenya,1 University of Oxford, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom2

Received 22 December 2008/ Returned for modification 14 March 2009/ Accepted 5 April 2009

We tested the effect of probenecid and verapamil in chemosensitizing Plasmodium falciparum to 14 antimalarials using the multidrug-resistant strain V1S and the drug-sensitive 3D7. Verapamil chemosensitizes V1S to quinine and chloroquine. Interestingly, probenecid profoundly chemosensitizes V1S to piperaquine. Thus, probenecid could be used to increase piperaquine efficacy in vivo.

* Corresponding author. Mailing address: Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program, P.O. Box 230, 80108 Kiilfi, Kenya. Phone: 254-41-522535. Fax: 254-41-522390. E-mail: anzila{at}kilifi.kemri-wellcome.org

{triangledown} Published ahead of print on 13 April 2009.

Antimicrobial Agents and Chemotherapy, July 2009, p. 3131-3134, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.01689-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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