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Antimicrobial Agents and Chemotherapy, July 2009, p. 3138-3139, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.00366-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Activity of SQ641, a Capuramycin Analog, in a Murine Model of Tuberculosis {triangledown}

Boris V. Nikonenko,* Venkata M. Reddy, Marina Protopopova, Elena Bogatcheva, Leo Einck, and Carol A. Nacy

Sequella, Inc., Rockville, Maryland

Received 17 March 2009/ Returned for modification 30 March 2009/ Accepted 28 April 2009

New delivery vehicles and routes of delivery were developed for the capuramycin analogue SQ641. While this compound has remarkable in vitro potency against Mycobacterium tuberculosis, it has low solubility in water and poor intracellular activity. We demonstrate here that SQ641 dissolved in the water-soluble vitamin E analogue {alpha}-tocopheryl polyethylene glycol 1000 succinate (TPGS) or incorporated into TPGS-micelles has significant activity in a mouse model of tuberculosis.

* Corresponding author. Mailing address: Sequella, Inc., 9610 Medical Center Drive, Suite 200, Rockville, MD 20852. Phone: (301) 762-7776. Fax: (301) 762-7778. E-mail: borisnikonenko{at}sequella.com

{triangledown} Published ahead of print on 4 May 2009.

Antimicrobial Agents and Chemotherapy, July 2009, p. 3138-3139, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.00366-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Young, L. S. (2009). Reconsidering Some Approved Antimicrobial Agents for Tuberculosis. Antimicrob. Agents Chemother. 53: 4577-4579 [Full Text]  


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