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Antimicrobial Agents and Chemotherapy, July 2009, p. 3147-3149, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.00023-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Emergence of Quinolone-Resistant Bordetella pertussis in Japan{triangledown}

Masayuki Ohtsuka,1,2 Ken Kikuchi,1* Kenichiro Shimizu,1 Namiko Takahashi,1 Yuka Ono,1 Takashi Sasaki,1 and Keiichi Hiramatsu1

Department of Infection Control Science, Faculty of Medicine, Juntendo University, 113-8421 Tokyo,1 Koto-biken Medical Laboratories Inc., Ibaraki, Japan2

Received 7 January 2009/ Returned for modification 21 March 2009/ Accepted 29 April 2009

Six Bordetella pertussis strains isolated from children in Japan from 2004 to 2006 showed high-level resistance to nalidixic acid (NAL; MIC, >256 µg/ml) and decreased susceptibilities to fluoroquinolones. All of the NAL-resistant strains had the same D87G mutation in gyrA.

* Corresponding author. Mailing address: Department of Infection Control Science, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan 113-8421. Phone: 81-3-5802-1041. Fax: 81-3-5684-7830. E-mail: kikuti{at}juntendo.ac.jp

{triangledown} Published ahead of print on 4 May 2009.

Antimicrobial Agents and Chemotherapy, July 2009, p. 3147-3149, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.00023-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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