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Antimicrobial Agents and Chemotherapy, July 2009, p. 3150-3152, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.01612-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Comparison of Tigecycline and Vancomycin for Treatment of Experimental Foreign-Body Infection Due to Methicillin-Resistant Staphylococcus aureus{triangledown}

Pierre Vaudaux,* Bénédicte Fleury, Asllan Gjinovci, Elzbieta Huggler, Manuela Tangomo-Bento, and Daniel P. Lew

Service of Infectious Diseases, University Hospitals of Geneva, CH-1211 Geneva 14, Switzerland

Received 5 December 2008/ Returned for modification 22 March 2009/ Accepted 4 April 2009

Twice-daily 7-day regimens of tigecycline (7 mg/kg) and vancomycin (50 mg/kg) were compared in a rat tissue cage model of chronic foreign-body infection due to methicillin (meticillin)-resistant Staphylococcus aureus strain MRGR3. Subcutaneously administered tigecycline reached levels in tissue cage fluid that were nearly equivalent or slightly superior to the antibiotic MIC (0.5 µg/ml) for strain MRGR3. After 7 days, equivalent, significant reductions in bacterial counts were recorded for tigecycline-treated and vancomycin-treated rats, compared with those for untreated animals.

* Corresponding author. Mailing address: Service of Infectious Diseases, University Hospitals of Geneva, 4 rue Gabrielle-Perret-Gentil, CH-1211 Geneva 14, Switzerland, Phone: 41-22 372 9826. Fax: 41-22 372 9830. E-mail: Pierre.Vaudaux{at}hcuge.ch

{triangledown} Published ahead of print on 13 April 2009.

Antimicrobial Agents and Chemotherapy, July 2009, p. 3150-3152, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.01612-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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