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Antimicrobial Agents and Chemotherapy, August 2009, p. 3569-3571, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00456-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Efficacy of Liposomal Amphotericin B Combined with Gamma Interferon or Granulocyte-Macrophage Colony-Stimulating Factor for Treatment of Systemic Zygomycosis in Mice{triangledown}

M. Mar Rodríguez,1 Enrique Calvo,1 Marçal Mariné,1 F. Javier Pastor,1 Joan Fernandez-Ballart,2 and Josep Guarro1*

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain,1 Unitat de Medicina Preventiva i Salut Pública, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain2

Received 6 April 2009/ Returned for modification 28 April 2009/ Accepted 12 May 2009

Granulocyte-macrophage colony-stimulating factor enhanced the efficacy of liposomal amphotericin B (LAMB) in a murine model of disseminated infection by Rhizopus oryzae, significantly prolonging survival and reducing tissue burden. The use of gamma interferon (IFN-{gamma}) alone was ineffective, and IFN-{gamma} combined with LAMB did not improve the results obtained with LAMB alone.

* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain. Phone: 977-759359. Fax: 977-759322. E-mail: josep.guarro{at}urv.cat

{triangledown} Published ahead of print on 18 May 2009.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3569-3571, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00456-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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