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Antimicrob Agents Chemother. 1974 October; 6(4): 393-396
Copyright © 1974 American Society for Microbiology. All Rights Reserved.

Cell Culture Studies on the Antiviral Activity of Ether Derivatives of 5-Hydroxymethyldeoxyuridine

J. B. Meldrum, V. S. Gupta and J. R. Saunders

Animal Pathology Division, Health of Animals Branch, Agriculture Canada, Saskatchewan Area Laboratory, and Departments of Veterinary Physiological Sciences Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N OWO, Canada

ABSTRACT

The antiviral activity of several ether derivatives of 5-hydroxymethyldeoxyuridine against the herpesvirus of infectious bovine rhinotracheitis was determined in monolayer cultures of secondary bovine fetal kidney cells. 5-Methoxy-methyldeoxyuridine (OCH3UdR) was found to be markedly inhibitory against this virus. Pretreatment of the cells with OCH3UdR, simultaneous addition of OCH3UdR with virus to the cells, and postinfection treatment with OCH3UdR were found to be effective in inhibiting virus-induced cytopathogenic effect. Against this virus, OCH3UdR was found to be as potent as 5-iododeoxyuridine and cytosine arabinoside. The {alpha}-anomer of OCH3UdR did not show antiviral activity. Preliminarly toxicity studies indicate that OCH3UdR has a very low acute toxicity.

Antimicrob Agents Chemother. 1974 October; 6(4): 393-396
Copyright © 1974 American Society for Microbiology. All Rights Reserved.





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