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Antimicrob Agents Chemother. 1975 January; 7(1): 55-57
Copyright © 1975 American Society for Microbiology. All Rights Reserved.

Comparative Effect of Tetracycline and Doxycycline on the Occurrence of Resistant Escherichia coli in the Fecal Flora

John G. Bartlett^*, Larry A. Bustetter, Sherwood L. Gorbach and Andrew B. Onderdonk

^* Infectious Diseases Section, Veterans Administration Hospital, Sepulveda, California 91343
University of California Medical Center, Los Angeles, California 90024

ABSTRACT

Antibiotic-induced changes in the fecal microflora after oral administration of tetracycline hydrochloride and doxycycline for 8 to 10 days were compared. A significant difference was noted in the concentrations of Escherichia coli resistant to tetracyclines. With tetracycline hydrochloride, there was a mean increase of approximately 10⁴ resistant strains per g compared to only 10¹/g for doxycycline. This difference is ascribed to reduced intestinal concentrations of bioactive drug with recommended oral dosage for doxycycline.

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Antimicrob Agents Chemother. 1975 January; 7(1): 55-57
Copyright © 1975 American Society for Microbiology. All Rights Reserved.