AAC Accepts, published online ahead of print on 16 June 2008
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Antimicrob. Agents Chemother. doi:10.1128/AAC.00036-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Molecular characterization of ofloxacin-resistant Mycobacterium tuberculosis strains from Russia

Igor Mokrousov*, Tatiana Otten, Olga Manicheva, Yulia Potapova, Boris Vishnevsky, Olga Narvskaya, and Nalin Rastogi*

Laboratory of Molecular Microbiology, St. Petersburg Pasteur Institute, 197101 St. Petersburg, Russia; Unité de la Tuberculose et des Mycobactéries, Institut Pasteur de Guadeloupe, Abymes 97183 Guadeloupe; and Laboratory of Microbiology of Tuberculosis, The Research Institute of Phthisiopulmonology, 193036 St. Petersburg, Russia

* To whom correspondence should be addressed. Email: igormokrousov{at}yahoo.com. nrastogi{at}pasteur-guadeloupe.fr.


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Abstract

Here, we studied a variation in the gyrA and gyrB genes in ofloxacin- and multidrug-resistant Mycobacterium tuberculosis strains circulating in North-West Russia. Comparison with spoligotyping data suggested that similar to the multidrug-resistant tuberculosis, a spread of the fluoroquinolone-resistant tuberculosis in Russia may be, at least partly, due to the prevalence of the Beijing genotype in a local population of M. tuberculosis.




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