AAC Accepts, published online ahead of print on 14 April 2008
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Antimicrob. Agents Chemother. doi:10.1128/AAC.00046-08
Copyright (c)2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Clonal Spread of Highly {beta}-Lactam-Resistant Streptococcus pneumoniae in Taiwan

Yu-Chia Hsieh, Kuang-Yi Chang, Yi-Chuan Huang, Hsiao-Chuan Lin, Yu-Huai Ho, Li-Min Huang*, and Po-Ren Hsueh*

Section of Infection, Department of Medicine, Wan-Fang Hospital, Taipei Medical University, Taipei; Division of Biostatistics, College of Public Health, National Taiwan University; Department of Anesthesiology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei; Division of Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung; Department of Pediatrics, China Medical University Hospital, Taichung; Department of Pediatrics, Buddhist Tzu Chi General Hospital, Hualien; Department of Pediatrics, National Taiwan University Hospital, Taipei; Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan

* To whom correspondence should be addressed. Email: lmhuang{at}ha.mc.ntu.edu.tw. hsporen{at}ntu.edu.tw.


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Abstract

This study aimed to evaluate the antimicrobial susceptibility profile of 364 Streptococcus pneumoniae isolates, and studied the genotypes of S. pneumoniae with high level {beta}-lactam resistance in Taiwan. Clonal complexes related to Spain23F-1, Taiwan19F-14, and Taiwan23F-15 were responsible for the spread of isolates with high {beta}-lactam resistance.