AAC Accepts, published online ahead of print on 7 July 2008

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Antimicrob. Agents Chemother. doi:10.1128/AAC.00117-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Emergence and acquisition of fluoroquinolone-resistant gram-negative bacilli in the intestinal tracts of mice treated with fluoroquinolone antimicrobial agents

Michael J. Pultz, Michelle M. Nerandzic, Usha Stiefel, and Curtis J. Donskey^*

Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio; Infectious Diseases Section, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio

^* To whom correspondence should be addressed. Email: curtisd123{at}yahoo.com.

After orogastric administration of a fluoroquinolone-resistant Klebsiella pneumoniae strain, subcutaneous ciprofloxacin, levofloxacin, and moxifloxacin promoted persistent low-density colonization in 10% to 40% of treated mice, whereas clindamycin consistently promoted high-density colonization. No emergence of fluoroquinolone-resistant gram-negative bacilli was detected during or after treatment with the fluoroquinolone antimicrobial agents.