AAC Accepts, published online ahead of print on 14 May 2007
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Antimicrob. Agents Chemother. doi:10.1128/AAC.00206-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Empiric Therapy with Trimethoprim-Sulfamethoxazole or Doxycycline for Outpatient Skin and Soft Tissue Infections in an Area of High MRSA Prevalence: A Prospective Randomized Trial

Mary Jo Cenizal, Daniel Skiest, Samuel Luber, Roger Bedimo, Pat Davis, Patrick Fox, Kathleen Delaney, and R. Doug Hardy*

The University of Texas Southwestern Medical Center, Dallas, TX

* To whom correspondence should be addressed. Email: robert.hardy{at}utsouthwestern.edu.


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Abstract

To evaluate empiric therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient SSTI in an area of high MRSA prevalence a randomized, prospective, open-label investigation was performed. The overall clinical failure rate was 9% with all failures occurring in the trimethoprim-sulfamethoxazole group. However, there was no significant difference in the clinical failure rate of empiric trimethoprim-sulfamethoxazole compared with doxycycline therapy.




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