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Antimicrob. Agents Chemother. doi:10.1128/AAC.00206-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Empiric Therapy with Trimethoprim-Sulfamethoxazole or Doxycycline for Outpatient Skin and Soft Tissue Infections in an Area of High MRSA Prevalence: A Prospective Randomized Trial

The University of Texas Southwestern Medical Center, Dallas, TX

^* To whom correspondence should be addressed. Email: robert.hardy{at}utsouthwestern.edu.

	Abstract

To evaluate empiric therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient SSTI in an area of high MRSA prevalence a randomized, prospective, open-label investigation was performed. The overall clinical failure rate was 9% with all failures occurring in the trimethoprim-sulfamethoxazole group. However, there was no significant difference in the clinical failure rate of empiric trimethoprim-sulfamethoxazole compared with doxycycline therapy.

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