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Antimicrob. Agents Chemother. doi:10.1128/AAC.00212-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Selective inhibition of porcine endogenous retrovirus (PERV) replication in human cells by acyclic nucleoside phosphonates

Frontier Science Research Center, Kagoshima University, Kagoshima 890-8544, Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan, and Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

^* To whom correspondence should be addressed. Email: m-baba{at}vanilla.ocn.ne.jp.

	Abstract

Several anti-human immunodeficiency virus type 1 reverse transcriptase inhibitors were evaluated for their antiviral activities against porcine endogenous retrovirus in human cells. Among the test compounds, zidovudine was found to be the most active. The order of potency was zidovudine > phosphonylmethoxyethoxydiaminopyrimidine = phosphonylmethoxypropyldiaminopurine > tenofovir adefovir > stavudine.